A mechanistic design principle for protein tyrosine kinase sensors: application to a validated cancer target.
نویسندگان
چکیده
A new mechanistic principle for reporting the phosphorylation of tyrosine is described, which should prove applicable to even the most fastidious of protein tyrosine kinases, as demonstrated by the acquisition of a fluorescent sensor for the extraordinarily demanding anaplastic lymphoma kinase.
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عنوان ژورنال:
- Organic letters
دوره 10 2 شماره
صفحات -
تاریخ انتشار 2008